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I've heard of people getting their bodies signed & then having it tattooed to make it permanent.
That's a bit extreme for me
I read of someone having their car signed (hard to frame )
For me it was a (new - with tags) pair of team boxer shorts signed by the football team. Granted, some of the players thought it was a bit strange, but satin boxers are surprisingly easy to sign, & are relatively small so are easy to frame.
I carried a large piece of Corian countertop material that I was using as a base for a Battlestar Galactica Viper model to a BSG con and had Jamie Bamber sign it. He remarked that "it was the first piece of granite he'd ever signed".
This doesn't really count, but my class had a day trip to Disney World. We had to do an assignment during the day, and we didn't carry much else. Me and my friend saw Stitch from Lilo and Stitch and really wanted his auto so we went up to him and he signed our assignments, of course at the time I didn't think about having to turn in the assignment which of course we had to do. It was also the end of the school year so I never got that paper back...sigh.
For something that does count, I was at a convention one time, waiting in line for autos, it's been a long time so I don't remember who I was in line to see. But I do remember that the girl in front of me, who was wearing a low cut top got the top ofher boob signed by the guy.
Autographs: Daniel Radcliffe, Pauley Perrette, Disney Princesses, Mary Costa, James Marsters, Doug Brochu, Heather Brewer, Robert Axelrod, Beth Revis, Judge Judy, Tara Strong, Josh Dallas, Helen McCrory, Zachary Levi, Maggie Smith, Jesse McCartney, Jodi Benson, Yuri Lowenthal, Michael Rosenbaum, Richard Armitage, Henry Cavill(sec?), Zoe Wanamaker, Jeremy Renner, Nicholas Hoult, Davo Okeniyi, Kenneth Branagh, Emma Thompson and a bunch of anime voice actors.