Arsenal's Nacho Monreal and Alex Oxlade-Chamberlain are doubtful with knee problems, while Kieran Gibbs is struggling with a ankle injury.
Goalkeeper Wojciech Szczesny (hip) and Mikel Arteta (calf) are both still out.
Southampton will be without Morgan Schneiderlin, who injured his thigh in Sunday's defeat to Manchester City.
The midfielder could be replaced by Jack Cork, who has recovered from illness or Harry Reed could also be called upon.
MATCH PREVIEW
Southampton suffered their heaviest defeat of the season at home to Manchester City on Sunday but this midweek fixture gives them a chance to bounce straight back.
And with Manchester United next up, and Chelsea to come later in the month, Saints will not want to suffer back-to-back defeats for the first time this season at the Emirates on Wednesday evening, although manager Ronald Koeman denies his side are feeling the pressure.
Arsenal's Nacho Monreal and Alex Oxlade-Chamberlain are doubtful with knee problems, while Kieran Gibbs is struggling with a ankle injury.
Goalkeeper Wojciech Szczesny (hip) and Mikel Arteta (calf) are both still out.
Southampton will be without Morgan Schneiderlin, who injured his thigh in Sunday's defeat to Manchester City.
The midfielder could be replaced by Jack Cork, who has recovered from illness or Harry Reed could also be called upon.
MATCH PREVIEW
Southampton suffered their heaviest defeat of the season at home to Manchester City on Sunday but this midweek fixture gives them a chance to bounce straight back.
And with Manchester United next up, and Chelsea to come later in the month, Saints will not want to suffer back-to-back defeats for the first time this season at the Emirates on Wednesday evening, although manager Ronald Koeman denies his side are feeling the pressure. :) ;-)